Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.
BackgroundHIV protease plastic molcajete bowls inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases.We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophag