INHIBITION OF P-GLYCOPROTEIN BY HIV PROTEASE INHIBITORS INCREASES INTRACELLULAR ACCUMULATION OF BERBERINE IN MURINE AND HUMAN MACROPHAGES.

Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.

BackgroundHIV protease plastic molcajete bowls inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases.We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophag

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Non-Invasive Iontophoretic Delivery of Cytochrome c to the Posterior Segment and Determination of Its Ocular Biodistribution

The intact porcine mike and ike mini packs eye globe model was used to demonstrate that transscleral iontophoresis could deliver a small protein, cytochrome c (Cyt c), to the posterior segment and to investigate post-iontophoretic biodistribution in the different ocular compartments.The effects of Cyt c concentration (1, 5, and 10 mg/mL), current d

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How Karen Tei Yamashita Literalizes Feminist Subversion: Extreme Domesticity, Space-Off Reversals, and Virtual Resistances in Tropic of Orange

In Tropic of Orange (1997), Karen Tei Yamashita builds an expansive narrative on the premise that the Tropic of Cancer shifts mysteriously from its actual latitude, barely north of Mazatlán, México, to that of L.A.’s latitude: from 23.43692° north of the Equator to 34.0522° N.By doing so, Yamashita literally takes that whi

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